The Sallusto Lab - Medical Immunology

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Group Latorre

Our work is focused on the understanding of the mechanisms that control T cell priming and regulate cytokine production and homing capacities. These questions are addressed primarily in the human system, where we combine the ex vivo analysis of memory T cell subsets with in vitro priming of naive T cells. This approach has led to the identification of chemokine receptors expressed in human Th17 and Th22 cells, and to the dissection of the cytokines that drive naive T cells polarization and modulate T cells effector functions. In parallel, we have used the mouse system to address fundamental questions on the regulation of lymphocyte trafficking during inflammation and in autoimmunity. We also developed a method for the analysis of human naive and memory CD4 and CD8 T cell repertoires based on high throughput cellular screenings of human T cell libraries. This method is currently used to dissect the human T cell response to pathogens, allergens, and self-antigens.