Oxenius Lab Research

Our Group focuses on the in vivo analysis of host-pathogen interactions for a variety of relevant pathogens. The main research goal is the elucidation of molecular, cellular and systemic mechanisms of innate and adaptive immune defense against acute and persistent viral or bacterial infections in relation to the dynamics of the infecting pathogen.

Funding:

ETH
external page SNF
external page Helmut Horten Stiftung
external page Heubergstiftung
external page Promedica

Projects

<p><span style="font-size: 11.0pt; line-height: 107%; font-family: "Calibri",sans-serif; mso-ascii-theme-font: minor-latin; mso-fareast-font-family: Calibri; mso-fareast-theme-font: minor-latin; mso-hansi-theme-font: minor-latin; mso-bidi-font-family: "Times New Roman"; mso-bidi-theme-font: minor-bidi; mso-ansi-language: EN-US; mso-fareast-language: EN-US; mso-bidi-language: AR-SA;">Upper left: <b style="mso-bidi-font-weight: normal;">NK cell-mediated regulation of CD8 T cell responses.</b> Confocal fluorescence microscopy of destruction of secondary lymphoid organ architecture by virus-specific T cells in absence of NK cells (from Pallmer et al., PLoS Pathogens, 2019, 15: e1007725) Upper right: <b style="mso-bidi-font-weight: normal;">Asymmetric CD8 T cell division and fate control.</b> Confocal fluorescence microscopy of mitotic phases of an activated CD8 T cell (from Borsa et al., 2019, Sci Immunol. 12;4(34)) Lower left: <b style="mso-bidi-font-weight: normal;">Adaptive immunity to cytomegalovirus infection.</b> Confocal fluorescence microscopy of CMV infected glandular epithelial cell (from Walton et al., PLoS Pathogens, 2011, 7: e1002214) Lower right: <b style="mso-bidi-font-weight: normal;">Regulation of adaptive immunity during chronic viral infections.</b> Confocal fluorescence microscopy of spleen germinal centers in absence or presence of follicular T helper cells. (from Greczmiel et al., Science Immunology, 2017 1;2(18)) </p> <p> </p> — Upper left: NK cell-mediated regulation of CD8 T cell responses. Confocal fluorescence microscopy of destruction of secondary lymphoid organ architecture by virus-specific T cells in absence of NK cells (from Pallmer et al., PLoS Pathogens, 2019, 15: e1007725) Upper right: Asymmetric CD8 T cell division and fate control. Confocal fluorescence microscopy of mitotic phases of an activated CD8 T cell (from Borsa et al., 2019, Sci Immunol. 12;4(34)) Lower left: Adaptive immunity to cytomegalovirus infection. Confocal fluorescence microscopy of CMV infected glandular epithelial cell (from Walton et al., PLoS Pathogens, 2011, 7: e1002214) Lower right: Regulation of adaptive immunity during chronic viral infections. Confocal fluorescence microscopy of spleen germinal centers in absence or presence of follicular T helper cells. (from Greczmiel et al., Science Immunology, 2017 1;2(18))