Spotlight
Inflammation shapes tolerance: CD8 T Cell Sensing of Type I Interferon Impacts Anergy
A study by the Oxenius group (IMB) published in the "European Journal of Immunology" reveals that baseline inflammation limits the induction of T cell tolerance. Basal IFN-I allows self-reactive T cells to expand and retain partial effector functions, linking baseline inflammation to autoimmunity.
Jörn Piel receives "Research Award of the Leibniz Research Network Bioactive Compounds"
Jörn Piel, Professor for Bacterial Natural Product Research at the Institute of Microbiology has been awarded for his pioneering work on bioactive natural products produced by bacteria
Beyond serology: unveiling the genetic blueprint of Escherichia coli’s outermost defense
Researchers from the Slack and Sunagawa groups presented a new tool - kTYPr - to map capsule serotypes in E. coli genomes. The study, published in Nature Microbiology, revives E. coli capsule research, revealing unprecedented genetic and ecologic diversity of these key virulence determinants.
An endangered natural pharmacy hidden in coral reefs
Researchers at ETH Zurich have identified hundreds of microbial species living among corals. These microbes produce a variety of substances with untapped potential for medicine and biotechnology, making the reef ecosystem even more valuable than previously recognised.
New Paper in Chem by the Piel Lab and the Sunagawa Lab
Widespread hypermodified β-helical peptides in common bacteria