Spotlight
Salmonella Typhimurium has a sweet tooth
A recent Nature Communications paper by the Hardt group (IMB), in collaboration with the Sauer group (IMSB) and the von Mering group (University of Zurich), highlights the essential role of monosaccharides in Salmonella Typhimurium colonization across various murine models with distinct gut microbiomes.
Mechanistic insights into noncanonical protein splicing by a radical SAM splicease
A recent Angewandte Chemie paper by the Vagstad and Piel groups (IMB) illuminates key mechanistic features of the unusual conversion of tyrosine residues to α-keto-β-amino acids by post-translational spliceases. Such ketoamide moieties are clinically used protease-inhibiting pharmacophores.
Millions of reconstructed genomes from diverse microbiomes at global scale
A recent “Nucleic Acids Research” paper by the Sunagawa group (IMB) showcases the new mOTUs online database (mOTUs-db), a resource which allows to select and download genomes from host- associated and environmental microbiomes, representing the largest prokaryotic genome collection to date.
Targeted Localization of the Mother Centrosome in CD8+ T Cells Undergoing Asymmetric Cell Division Promotes Memory Formation
A recent "Cell Reports" paper by the Oxenius group (IMB) demonstrates a role of targeted centrosome inheritance during CD8+ T cell division for the generation of memory precursor cells.
New Paper in Angew Chem Int Ed.
Mechanistic Insights Into Post-translational α-Keto-β-Amino Acid Formation by a Radical S-Adenosyl Methionine Peptide Splicease