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Spotlight
Evolution-guided engineering of trans-acyltransferase polyketide synthases
The publication in Science by the Piel group (IMB) in collaboration with the Piechulla (University of Rostock) and Walker group (Vanderbilt University) reports a method that permits the construction of tailored bacterial biosynthetic pathways for structurally complex polyketide metabolites, based on ways how modular megaenzymes evolve naturally.
Julia Vorholt receives the Feodor Lynen Medal
Julia Vorholt has been awarded the Feodor Lynen Medal 2024 for her work in the field of biochemistry. Congratulations!
Assessing microbiome population dynamics using genomic WISH-tags
To study the dynamics of microbiome assembly with strain-level resolution, the Vorholt, Hardt, and Sunagawa labs (all IMB) jointly developed a novel genomic barcoding system, the WISH-tags. These were used to assess how the order of arrival order impacts colonization in plant and mammalian microbiomes.
New paper in Cell Reports by the Hardt Lab
Salmonella T3SS-2 virulence enhances gut-luminal colonization by enabling chemotaxis-dependent exploitation of intestinal inflammation