News & Events
Spotlight
New Paper in Chem by the Piel Lab and the Sunagawa Lab
Widespread hypermodified β-helical peptides in common bacteria
New Paper in PLOS Pathogens by the Hardt Lab
TTSS-2 virulence drives inflammatory destruction of the gut epithelial barrier and modulates inflammatory response profiles in the Salmonella-infected mouse gut
Reducing carbon loss during bioconversion of CO2-derived methanol
Formate accumulation limits bioproduction from CO₂-derived methanol. Keller and Hegedis et al. discovered that NAD-dependent methanol dehydrogenases overoxidize methanol to formate—and found non-overoxidizing variants that have the potential to boost process yields.
Pathogenic beginnings: a fungus-bacterium merger shifts toward coexistence
By introducing free-living bacteria into fungal cells, Gassler et al. reveal early endosymbiogenesis steps. Despite initial host stress, vertical transmission occurs and fitness improves over time as defense responses attenuate, revealing a transition from antagonism towards commensalism.